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Клетки эндотелия пупочной вены человека: HUVEC. Первичные клеточные линии Cell Applications.

Human Umbilical Vein Endothelial Cells: HUVEC

HUVEC Клетки Эндотелия Пупочной Вены Человека (HUVEC) предоставляют классическую модельную систему для изучения многих аспектов функций и заболеваний эндотелия, таких как нормальный, аномальный и связанных с опухолями ангиогенез, оксидативный стрес, гипоксия и воспаления, связанные с ними сигнальные пути в эндотелии в нормальных и патологических условиях, связанные с сердечно-сосудистые осложнения, связанные с различными заболеваниями, способы действия и защитные эффекты различных соединений и т.д.  Избранные лоты HUVEC были дополнительно тестированы для демонстрации стимуляционно-зависимого ангиогенеза и ключевых для эндотелиальных клеток сигнальных путей (фосфорилирование VEGFR, Akt, MAPK, и экспрессию Tie2, eNOS, Axl и Etk/Bmx). Более подробную информацию смотрите в разделе Тестированные Эндотелиальные Клетки.

HUVEC от Cell Applications, Inc. были использованы во многих исследованиях, например:

(Текст на языке оригинала)
  • Understand anti-inflammatory properties of HDL
  • Develop scaffolds for tissue engineering
  • Characterize endothelial cell response to stress and discover mechanisms that protect mitochondria against oxidative stress
  • Demonstrate that prolonged hypoxia induces MMP-1 expression, EC migration and angiogenesis
  • Show that Alzheimer’s β-amyloid peptide exhibits anti-angiogenic properties
  • Demonstrate for the first time that mature miRNA can control gene expression in a cell where it is neither transcribed nor processed
  • Show that abnormal matrix composition characteristic for systemic sclerosis leads to impaired vascular function and angiogenesis
  • Discover novel mechanisms of inhibiting tumor angiogenesis and metastasis, by limiting EC migration and proliferation, as well as the expression of growth factors and enzymes
  • Develop a bubble lyposome based system that enables therapeutic miRNA delivery
  • Demonstrate that commercially used flame retardants cause oxidative stress
  • Show that hyperglycemia leads to endothelial dysfunction, partially due to depletion of antioxidants, and that regaining glycemic control normalizes growth factor levels in ischemia and improves perfusion recovery
  • Show that inhibition of aldose reductase inhibits migration and formation of capillary-like structures by endothelial cells
  • Investigate effects of molecular mobility of the outmost material surfaces on cellular adhesion and organization
  • Identify signaling differences in cells cultured on different ECM components.
  • Investigate mechanisms of cardiovascular protection exerted by bioactive plant and fungal components
  • Show that in low doses coumaric acid and resveratrol provide beneficial effects and protect endothelial cells from reactive oxygen species
  • Show that combined treatment with melatonin and atorvastatin reversed damage to EC, partly by reducing free radical generation and lipid peroxidation
  • Discover that deferoxamine (DFO), an iron-chelating agent, mitigates deleterious effects of radiation on angiogenesis
  • Study the differential effects of wood smoke and diesel exhaust particles, as well as carbon nanotubes on inducing oxidative stress and production of cytokines and adhesion molecules in endothelia

Параметры

Tissue:
Human normal umbilical vein.  Each lot is tested negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Cryopreserved ampoule:
Primary culture, >500,000 cells in Endothelial Cell Basal Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved HUVEC (200-05n), 500 ml Endothelial Cell Growth Medium (211-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
Shipped in Endothelial Cell Transfer Medium at 1st passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 16 doublings


Документы



Публикации

2016
Lansford, K., D. Shill, A. Dicks, M. Marshburn, W. Southern. And N. Jenkins. 2016. Effect of acute exercise on circulating angiogenic cell and microparticle populations. Experimental Physiology, 101:155-167.
2015
Basudhara, D., R. Chengb, G. Bharadwaja, L. Ridnourb, D. Winkb, and K. Mirandaa. 2015. Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer. Free Radical Biology and Medicine, 4 February.
Berg, E., M. Polokoff, A. O’Mahony, D. Nguyen, and X Li. 2015. Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects. International, Journal of Molecular Sciences, 16:1008-1029.
Boire, T., M. Gupta, A. Zachman, S. Lee, D. Balikov, K. Kim, L. Bellan, and H. Sung. 2015. Pendant Allyl Crosslinking as a Tunable Shape Memory Actuator for Vascular Applications. Acta Biomaterialia, doi:10.1016/j.actbio.2015.06.004.Dokun, A., L. Chen, M. Okutsu, C. Farber, S. Hazarika, W. Jones, D. Craig, D. Marchuk, J. Lye, S. Shan, and B. Annex. 2015. ADAM12: A Genetic Modifier of Pre-clinical Peripheral Arterial Disease. Am J Physiol, DOI: 10.1152/ajpheart.00803.2014.
Huang, B., J. Cheng, C. Wu, P. Chen, P. Tu, Y. Fu, and C. Wu. 2015. Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascular Pharmacol, doi:10.1016/j.vph.2015.07.014.
Kim, K., Y. Lee, H. Ji, R. Song, J. Kim, S. Lee, S. Hong, M. Yoo, and H. Yang. 2015. Increased expression of endocan in arthritic synovial tissues: Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes. Molecular Medicine Reports, 11:2695-2702.
Klingberg, H., L. Oddershede, K. Loeschner, E. Larsen, S. Lofta, and Møller. 2015. Uptake of gold nanoparticles in primary human endothelial cells. Toxicology Research, Advance Article, DOI: 10.1039/C4TX00061G.
Liu, Y., Q. Chen, M. Xu, G. Guan, W. Hu, Y. Liang, X. Zhao, M. Qiao, D. Chen, and H. Liu. 2015. Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells. International Journal of Nanomedicine, 10:1855-1867.
2014
Cao, Y., N.R. Jacobsen, P.H. Danielsen, A.G. Lenz, T. Stoeger, S. Loft, H. Wallin, M. Roursgaard, L. Mikkelsen, and P. Møller. 2014. Vascular Effects of Multiwalled Carbon Nanotubes in Dyslipidemic ApoE −/− Mice and Cultured Endothelial Cells. Toxicological Sciences. 138:104-116.
Cha, B., H. Kwak, A. Park, S. Kim, S. Park, H. Kim, I. Kim, K. Lee, and Y. Park. 2014. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers, 101:307-318.
Dokun, A. L. Chen, S. Lanjewar, J. Lye, and B. Annex. 2014. Glycemic Control Improves Perfusion Recovery and VEGFR2 Protein Expression in Diabetic Mice Following Experimental PAD. Cardiovascular Research, 101:364-372.
Endo-Takahashi, Y., Y. Negishi, A. Nakamura, S. Ukai, K. Ooaku, Y. Oda, K. Sugimoto, F. Moriyasu, N. Takagi, R. Suzuki, K. Maruyama, and Y. Aramaki. 2014.   Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Scientific Reports 4, Article number: 3883.
Lu, J., X Li, Y. Jin, and M. Chen. 2014. Endoplasmic reticulum stress-mediated aldosterone-induced apoptosis in vascular endothelial cells. J. Huazhong Univ Sci Technol, 34:821-824.
Sahara, M. E. Hansson, O. Wernet, K. Lui, D. Später, and K. Chien. 2014. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Research, 24:820-841.
Sasahira, T., N. Ueda, K. Yamamoto, M. Kurihara, S. Matsushima, U.K. Bhawal, T. Kirita, and H. Kuniyasu. 2014. Prox1 and FOXC2 Act as Regulators of Lymphangiogenesis and Angiogenesis in Oral Squamous Cell Carcinoma. PloS one. 9:e92534.
Savoji, H., A. Hadjizadeh, M. Maire, A. Ajji, M. Wertheimer, and S. Lerouge. 2014. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts. Macromolecular Bioscience, 14:1084-1095.
Tabet, F., K.C. Vickers, L.F. Cuesta Torres, C.B. Wiese, B.M. Shoucri, G. Lambert, C. Catherinet, L. Prado-Lourenco, M.G. Levin, S. Thacker, P. Sethupathy, P.J. Barter, A.T. Remaley, and K.-A. Rye. 2014. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nat Commun. 5:10.1038/ncomms4292.
Takemoto, K., S. Kamisuki, P. Chia, I. Kuriyama, Y. Mizushina, and F. Sugawara. 2014. Bioactive Dihydronaphthoquinone Derivatives from Fusarium solani. J Nat Prod, 77:1992-1996.
Yin, C., Y. Liang, S. Guo, X. Zhou, and X. Pan. 2014. CCN1 enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Molecular Biology Reports, 41:5813-5818.
Zhen, A., S. Krutzik, B. Levin, S. Kasparian, J. Zack, and X. Kitchen. 2014. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol, 88:9934-9946.
2013
Cha, B.G., H.W. Kwak, A.R. Park, S.H. Kim, S.Y. Park, H.J. Kim, I.S. Kim, K.H. Lee, and Y.H. Park. 2013. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract 6. Peptide Science:DOI: 10.1002/bip.22359.
Chen, Z., T.C. Lai, Y.H. Jan, F.M. Lin, W.C. Wang, H. Xiao, Y.T. Wang, W. Sun, X. Cui, Y.S. Li, T. Fang, H. Zhao, C. Padmanabhan, R. Sun, D.L. Wang, H. Jin, G.Y. Chau, H.D. Huang, M. Hsiao, and J.Y.J. Shyy. 2013. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. The Journal of clinical investigation. 123:1057-1067.
Kaakinen, M., S. Huttunen, L. Paavolainen, V. MarjomÄKi, J. HeikkilÄ, and L. Eklund. 2013. Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches. Journal of Microscopy. 253:65-78.
Lohr, N.L., J.T. Ninomiya, D.C. Warltier, and D.e. Weihrauch. 2013. Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb 2. Journal of Molecular and Cellular Cardiology. 62:36-42.
Mazor, R., T. Alsaigh, H. Shaked, A.E. Altshuler, E.S. Pocock, E.B. Kistler, M. Karin, and G.W. Schmid-Sch+Ýnbein. 2013. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. The Journal of biological chemistry. 288:598-607.
Nakayama, K. 2013a. cAMP-response Element-binding Protein (CREB) and NF-κB Transcription Factors Are Activated during Prolonged Hypoxia and Cooperatively Regulate the Induction of Matrix Metalloproteinase MMP1. Journal of Biological Chemistry. 288:22584-22595.
Nakayama, K. 2013b. CREB and NF-κB are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. Journal of Biological Chemistry. 288:22584-22589.
Pallet, N., I. Sirois, C. Bell, L.l.A.c. Hanafi, K. Hamelin, M. Dieud+ª, C. Rondeau, P. Thibault, M. Desjardins, and M.J.e. Hebert. 2013. A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells 7. PROTEOMICS. 13:1108-1120.
Takizawa, Y., Y. Kosuge, H. Awaji, E. Tamura, A. Takai, T. Yanai, R. Yamamoto, K. Kokame, T. Miyata, and R. Nakata. 2013. Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. The British journal of nutrition:1-6.
Tseng, A.H.H., S.-S. Shieh, and D.L. Wang. 2013. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radical Biology and Medicine. 63:222-234.
Vargas-Pinto, R., H. Gong, A. Vahabikashi, and M. Johnson. 2013. The Effect of the Endothelial Cell Cortex on Atomic Force Microscopy Measurements 3. Biophysical Journal. 105:300-309.
Whitsett, J., A. Rangel Filho, S. Sethumadhavan, J. Celinska, M. Widlansky, and J. Vasquez-Vivar. 2013. Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. Free Radical Biology and Medicine. 63:143-150.
2012
Bernson, E. 2012. Development of a Microfluidic Platform for Cell migration Studies along Gradients. In Department of Applied Physics. MS Thesis, Chalmers University of Technology.
Cossu, A. 2012. Study of intracellular signaling pathways triggered by natural antioxidants in human endothelial cells. Università degli studi di Sassari, PhD dissertation.
Ding, S., D.M. Pinkas, and A.E. Barron. 2012. Synthesis and assembly of functional high molecular weight adiponectin multimers in an engineered strain of Escherichia coli. Biomacromolecules. 13:1035-1042.
Donneys, A., D.M. Weiss, S.S. Deshpande, S. Ahsan, C.N. Tchanque-Fossuo, D. Sarhaddi, B. Levi, S.A. Goldstein, and S.R. Buchman. 2012. Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy. Bone. 52:318–325.
Forchhammer, L., S. Loft, M. Roursgaard, Y. Cao, I.S. Riddervold, T. Sigsgaard, and P. Møller. 2012. Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter. Toxicology letters. 209:121-128.
Hisano, Y., N. Kobayashi, A. Yamaguchi, and T. Nishi. 2012. Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells. PloS one. 7:e38941.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012.  Inhibiting Aberrant Blood Vessel Formation Using Growth Factor Retargeted Endopeptidases. Patent Applications US 20120207704 A1. 
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012.   Treating a Disease of Hyperproliferation Using Retargeted Endopeptidases. Patent Application US 20120207733 A1.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012.  Methods of Inhibiting Aberrant Blood Vessel Formation Using Opioid Retargeted Endpeptidases. Patent Application US 20120207734 A1.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, G. Sachs, K. Aoki, and E. Fernandez-Salas. 2012.   Treatments Using PSMA Ligand Endopeptidases. US 20120207742 A1. 
Kawaguchi, K., F. Lambein, and K. Kusama-Eguchi. 2012. Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. Biochemical and biophysical research communications. 428:160-166.
Murai, A., S. Asa, A. Kodama, A. Hirata, T. Yanai, and H. Sakai. 2012. Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. BMC Veterinary Research. 8:128.
Nakamura, D.S., A.K. Edwards, S. Virani, R. Thomas, and C. Tayade. 2012. Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model. The American journal of pathology. 181:570-582.
Namin, S.M. 2012. An Experimental and Theoretical Analysis of Nitric Oxide in the Microcirculation. PhD Dissertation, Florida International University.
Paolillo, R., M. Lovene, C. Carratelli, and A. Rizzo. 2012. Induction of VEGF and MMP-9 Expression by Toll-like Receptor 2/4 in Human Endothelial Cells Infected with Chlamydia Pneumoniae. Intl J Immunopathol & Pharmacol, 25:377-386.
Pfister, C., H. Pfrommer, M. Tatagiba, and F. Roser. 2012. Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitro. British journal of cancer. 107:1702-1713.
Siegel, D., J.K. Kepa, and D. Ross. 2012. NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Localizes to the Mitotic Spindle in Human Cells 1. PloS one. 7:e44861.
Shao, M., S. Hollar, D. Chambliss, J. Schmitt, R. Emerson, B. Chelladurai, S. Perkins, M. Ivan, and D. Matei. 2012. Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer. Molecular Cancer Therapeutics. 11:1576-1586. 
Takino, J., S. Yamagishi, and M. Takeuchi. 2012. Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression. World journal of gastroenterology: WJG. 18:1781.
Wang, X., Z. Zhang, and C. Yao. 2012. Bortezomib Inhibits the Angiogenesis Mediated by Mesenchymal Stem Cells. Cellular and Molec Biol, 30:657-662.
Xie, W., Z. Zhai, Y. Yang, T. Kuang, and C. Wang. 2012. Free fatty acids inhibit TM–EPCR expression through JNK pathway: an implication for the development of the prothrombotic state in metabolic syndrome. Journal of thrombosis and thrombolysis. 34:468-474.
2011
Dayoub, J.C., F. Ortiz, L.C. L+Ýpez, C. Venegas, A. del Pino-Zumaquero, O. Roda, I. S+¡nchez-Montesinos, D.o. Acu+Ýa-Castroviejo, and G. Escames. 2011. Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide 9. Journal of Pineal Research. 51:324-330.
Jane, E.P., D.R. Premkumar, and I.F. Pollack. 2011. Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway. Molecular Cancer Therapeutics. 10:198-208.
Konakahara, S., M. Saitou, S. Hori, T. Nakane, K. Murai, R. Itoh, A. Shinsaka, J. Kohroki, T. Kawakami, M. Kajikawa, and Y. Masuho. 2011. A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization. FEBS letters. 585:2377-2384.
Mehta, R.R., T. Yamada, B.N. Taylor, K. Christov, M.L. King, D. Majumdar, F. Lekmine, C. Tiruppathi, A. Shilkaitis, and L. Bratescu. 2011. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 14:355-369.
Mikkelsen, L., M. Sheykhzade, K.A. Jensen, A.T. Saber, N.R. Jacobsen, U. Vogel, H. Wallin, S. Loft, and P. Moller. 2011. Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2. Part Fibre Toxicol. 8:32.
Mukai, R., H. Ashida, J. Terao, and N. Saito. 2011. Determination of Subcellular Localization of Flavonol in Cultured Cells by Laser Scanning. In Laser Scanning, Theory and Applications. C. Wang (Ed.), ISBN: 978-953-307-205-0.
Pauken, C.M., and M.R. Caplan. 2011. Temporal differences in Erk1/2 activity distinguish among combinations of extracellular matrix components. Acta Biomaterialia. 7:3973-3980.
Rivera, V.M., R.M. Squillace, D. Miller, L. Berk, S.D. Wardwell, Y. Ning, R. Pollock, N.I. Narasimhan, J.D. Iuliucci, and F. Wang. 2011. Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Molecular cancer therapeutics. 10:1059-1071.
Rössler, J., Y. Monnet, F. Farace, P. Opolon, E. Daudigeos-Dubus, A. Bourredjem, G. Vassal, and B. Geoerger. 2011. The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts. International Journal of Cancer. 128:2748-2758.
Sanna, V., G. Pintus, A.M. Roggio, S. Punzoni, A.M. Posadino, A. Arca, S. Marceddu, P. Bandiera, S. Uzzau, and M. Sechi. 2011. Targeted biocompatible nanoparticles for the delivery of (−)-epigallocatechin 3-gallate to prostate cancer cells. Journal of medicinal chemistry. 54:1321-1332.
Sharma, V., and H.H. Freeze. 2011a. Mannose Efflux from the Cells: A POTENTIAL SOURCE OF MANNOSE IN BLOOD. Journal of Biological Chemistry. 286:10193-10200.
Sharma, V., M. Ichikawa, P. He, Y. Bravo, R. Dahl, B. Ng, N. Cosford, and H. Freeze. 2011. Phosphomannose Isomerase Inhibitors Improve N-Glycosylation in Selected Phosphomannomutase-deficient Fibroblasts. JCB, 286:39431-39438.
Xu, H., M. Zaidi, J. Struve, D.W. Jones, J.G. Krolikowski, S. Nandedkar, N.L. Lohr, A. Gadicherla, P.S. Pagel, M.E. Csuka, K.A. Pritchard, and D. Weihrauch. 2011. Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. American Journal of Physiology - Cell Physiology. 300:C550-C556.
Yoshikawa, A., Y. Aizaki, K.-i. Kusano, F. Kishi, T. Susumu, S. Iida, S. Ishiura, S. Nishimura, M. Shichiri, and T. Senbonmatsu. 2011. The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space. Hypertension research. 34:599-605.
2010
Edwards, D., M. Berens, and C. Beaudry. 2010. Cell migration inhibiting compositions and methods and compositions for treating cancer. Patent US 7700615 B2.
Heberlein, K., A. Straubb, A. Best, M. Greyson, R. Looft-Wilson, P. Sharma, A. Meher, N. Leitinger, and B. Isakson. 2010. Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation. Circulation Research, 106:1092-1102.
Jacky, B., P. Garay, Y. Molina, D. Stathakis, J. Francis, K. Aoki, and E. Fernandez-Salas. 2010. Methods of Treating Cancer Using Opioid Retargeted Endopepidases. Patent Application US 20110064713 A1.
Jacky, B. P. Garay, Y. Molina, D. Stathakis, J. Francis, K. Aoki, and E. Fernandez-Salas. 2010. Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopeptidases. Patent Application US 20110070212 A1.
Koai, E., T. Rios, and J. Edwards. 2010. Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells. WebmedCentral PHYSIOLOGY 2010;1(11):WMC001111, doi: 10.9754/journal.wmc.2010.001111.
Lionetti, V., S. Cantoni, C. Cavallini, F. Bianchi, S. Valente, I. Frascari, E. Olivi, G. Aquaro, F. Bonavita, I. Scarlata, M. Maioli, V. Vaccari, R. Tassinari, A. Bartoli, F. Recchia, G. Pasquinelli, and C. Ventura. 2010. Hyaluronan Mixed Esters of Butyric and Retinoic Acid Affording Myocardial Survival and Repair without Stem Cell Transplantation. JBC, 285:9949-9961.
Miyake, Y., M. Mochizuki, C. Ito, M. Itoigawa, and T. Osawa. 2010. Peroxynitrite Scavengers Produced by Filamentous Fungus Used in the Katsuobushi Manufacturing Process. Food science and technology research. 16:493-498.
Mochizuki, M., Y. Tsuchie, N. Yamada, Y. Miyake, and T. Osawa. 2010. Effect of sesame lignans on TNF-α-induced expression of adhesion molecules in endothelial cells. Bioscience, biotechnology, and biochemistry. 74:1539-1544.
Nivison-Smith, L., J. Rnjak, and A.S. Weiss. 2010. Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications. Acta Biomaterialia. 6:354-359.
Pasciu, V., A.M. Posadino, A. Cossu, B. Sanna, B. Tadolini, L. Gaspa, A. Marchisio, S. Dessole, G. Capobianco, and G. Pintus. 2010. Akt Downregulation by Flavin Oxidase–Induced ROS Generation Mediates Dose-Dependent Endothelial Cell Damage Elicited by Natural Antioxidants. Toxicological Sciences. 114:101-112.
Patel, N.S., V.S. Mathura, C. Bachmeier, D. Beaulieu-Abdelahad, V. Laporte, O. Weeks, M. Mullan, and D. Paris. 2010. Alzheimer’s β-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. Journal of Neurochemistry. 112:66-76.
Sheikh-Ali, M., S. Sultan, A.-R. Alamir, M.J. Haas, and A.D. Mooradian. 2010a. Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells. Diabetes research and clinical practice. 87:161-166.
Sheikh-Ali, M., S. Sultan, A.-R. Alamir, M.J. Haas, and A.D. Mooradian. 2010b. Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells. Nutrition. 26:1146-1150.
Thebaud, N. 2010. Cellules endothéliales issues de progéniteurs humains : des acteurs pertinents en ingénierie vasculaire? PhD Dissertation, L’UNIVERSITÉ BORDEAUX 2.
Zhang, Y., W. Schulte, D. Pink, K. Phipps, A. Zijlstra, J.D. Lewis, and D.M. Waisman. 2010. Sensitivity of Cancer Cells to Truncated Diphtheria Toxin. PloS one. 5:e10498.
2009
Himmelhaus, M., and A. Francois. 2009. In-vitro sensing of biomechanical forces in live cells by a whispering gallery mode biosensor. Biosensors and Bioelectronics. 25:418-427.
Himmelhaus, M., and A. Francois. 2009. Method for sensing a biochemical and/or biomechanical process of a biological material and method for analyzing biological materials. Patent Application US 20110256577 A1.
Islam, M.K., N. Tsuji, T. Miyoshi, M.A. Alim, X. Huang, T. Hatta, and K. Fujisaki. 2009. The Kunitz-Like Modulatory Protein Haemangin Is Vital for Hard Tick Blood-Feeding Success. PLoS Pathog. 5:e1000497.
Kawashiro, Y., H. Fukata, K. Sato, H. Aburatani, H. Takigami, and C. Mori. 2009. Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells. Human & Experimental Toxicology. 28:703-713.
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Wu, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz, and J.P. Cooke. 2009. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. Journal of cellular biochemistry. 108:433-446.
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Yoshie, M., E. Miyajima, S. Kyo, and K. Tamura. 2009. Stathmin, a Microtubule Regulatory Protein, Is Associated with Hypoxia-Inducible Factor-1α Levels in Human Endometrial and Endothelial Cells. Endocrinology. 150:2413-2418.
2008
Kim, C.-S., S.-B. Jung, A. Naqvi, T.A. Hoffman, J. DeRicco, T. Yamamori, M.P. Cole, B.-H. Jeon, and K. Irani. 2008. P53 Impairs Endothelium-Dependent Vasomotor Function Through Transcriptional Upregulation of P66shc. Circulation research. 103:1441-1450.
Madasamy, S. 2008. Multi-subunit biological complexes for treatment of plaque-associated diseases. Patent Application US 20090104121 A1.
Rocha, F.G., C.A. Sundback, N.J. Krebs, J.K. Leach, D.J. Mooney, S.W. Ashley, J.P. Vacanti, and E.E. Whang. 2008. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials. 29:2884-2890.
Syeda, F., E. Tullis, A.S. Slutsky, and H. Zhang. 2008. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. Am J Physiol 294:H2769-H2774.
Yamanaka, M., Y. Anada, Y. Igarashi, and A. Kihara. 2008. A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. Biochemical and biophysical research communications. 375:675-679.
2007
Ali, M.A., H. Choy, A.A. Habib, and D. Saha. 2007. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia (New York, NY). 9:370.
Carratelli, C.R., R. Paolillo, and A. Rizzo. 2007. Chlamydia pneumoniae stimulates the proliferation of HUVEC through the induction of VEGF by THP-1. International Immunopharmacology. 7:287-294.
Hollingsworth, J.W., Z. Li, D.M. Brass, S. Garantziotis, S.H. Timberlake, A. Kim, I. Hossain, R.C. Savani, and D.A. Schwartz. 2007. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. American journal of respiratory cell and molecular biology. 37:248.
Hong, T.-M., Y.-L. Chen, Y.-Y. Wu, A. Yuan, Y.-C. Chao, Y.-C. Chung, M.-H. Wu, S.-C. Yang, S.-H. Pan, J.-Y. Shih, W.-K. Chan, and P.-C. Yang. 2007. Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer. Clinical Cancer Research. 13:4759-4768.
Mattagajasingh, I., C.-S. Kim, A. Naqvi, T. Yamamori, T.A. Hoffman, S.-B. Jung, J. DeRicco, K. Kasuno, and K. Irani. 2007. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences. 104:14855-14860.
Omori, N., H. Fukata, K. Sato, K. Yamazaki, K. Aida-Yasuoka, H. Takigami, M. Kuriyama, M. Ichinose, and C. Mori. 2007. Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells. Human & Experimental Toxicology. 26:811-816.
Shibata, M., J. Morimoto, H. Doi, S. Morishima, M. Naka, and Y. Otsuki. 2007. Electrogene therapy using endostatin, with or without suicide gene therapy, suppresses murine mammary tumor growth and metastasis. Cancer Gene Therapy, 14:268-278.
Wu, X., K. Mahadev, L. Fuchsel, R. Ouedraogo, S.-q. Xu, and B.J. Goldstein. 2007. Adiponectin suppresses IκB kinase activation induced by tumor necrosis factor-α or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. American Journal of Physiology - Endocrinology and Metabolism. 293:E1836-E1844.
Zhao, X., J. Hu, and L. Yang. Identification of One Vasculature Specific Phage-displayed Peptide in Human Colon Cancer. J. Exp. Clin. Cancer Res., 26:509-514.
2006
Kamiyoshi, A., T. Sakurai, Y. Ichikawa-Shindo, J. Fukuchi, H. Kawate, S.-i. Muto, Y.-i. Tagawa, and T. Shindo. 2006. Endogenous αCGRP protects against concanavalin A-induced hepatitis in mice. Biochemical and biophysical research communications. 343:152-158.
Edwards, D., M. Berens, and C. Beaudry. 2006. Cell migration inhibiting compositions and methods and compositions for treating cancer. Patent US 7012100 B1.
Haas, M.J., M.H. Horani, S.A. Parseghian, and A.D. Mooradian. 2006. Statins Prevent Dextrose-Induced Endothelial Barrier Dysfunction, Possibly Through Inhibition of Superoxide Formation. Diabetes. 55:474-479.
Horani, M.H., M.J. Haas, and A.D. Mooradian. 2006a. Saturated, unsaturated, and trans-fatty acids modulate oxidative burst induced by high dextrose in human umbilical vein endothelial cells. Nutrition. 22:123-127.
Horani, M.H., M.J. Haas, and A.D. Mooradian. 2006b. Suppression of Hyperglycemia-Induced Superoxide Formation and Endothelin-1 Gene Expression by Carvedilol. American Journal of Therapeutics. 13:2-7.
Shibata, M.-A., Y. Ito, J. Morimoto, K. Kusakabe, R. Yoshinaka, and Y. Otsuki. 2006b. In vivo electrogene transfer of interleukin-12 inhibits tumor growth and lymph node and lung metastases in mouse mammary carcinomas. The journal of gene medicine. 8:335-352.
2005
Bernier, S.G., N. Taghizadeh, C.D. Thompson, W.F. Westlin, and G. Hannig. 2005. Methionine aminopeptidases type I and type II are essential to control cell proliferation. Journal of cellular biochemistry. 95:1191-1203.
Csiszar, A., K.E. Smith, A. Koller, G. Kaley, J.G. Edwards, and Z. Ungvari. 2005. Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells: Role of Nuclear Factor-κΒ Activation by Tumor Necrosis Factor-α, H2O2, and High Intravascular Pressure. Circulation. 111:2364-2372.
Kawamura, Y.I., R. Kawashima, R. Fukunaga, K. Hirai, N. Toyama-Sorimachi, M. Tokuhara, T. Shimizu, and T. Dohi. 2005. Introduction of Sda Carbohydrate Antigen in Gastrointestinal Cancer Cells Eliminates Selectin Ligands and Inhibits Metastasis. Cancer research. 65:6220-6227.
Miho, N., T. Ishida, N. Kuwaba, M. Ishida, K. Shimote-Abe, K. Tabuchi, T. Oshima, M. Yoshizumi, and K. Chayama. 2005. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells. Cardiovascular Research. 68:289-298.
Papaconstantinou, M.E., C.J. Carrell, A.O. Pineda, K.M. Bobofchak, F.S. Mathews, C.S. Flordellis, M.E. Maragoudakis, N.E. Tsopanoglou, and E. Di Cera. 2005. Thrombin Functions through Its RGD Sequence in a Non-canonical Conformation. Journal of Biological Chemistry. 280:29393-29396.
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2004
Han, K.H., K.-H. Hong, J.-H. Park, J. Ko, D.-H. Kang, K.-J. Choi, M.-K. Hong, S.-W. Park, and S.-J. Park. 2004. C-Reactive Protein Promotes Monocyte Chemoattractant Protein-1—Mediated Chemotaxis Through Upregulating CC Chemokine Receptor 2 Expression in Human Monocytes. Circulation. 109:2566-2571.
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Gustafson, D.L., D. Siegel, J.C. Rastatter, A.L. Merz, J.C. Parpal, J.K. Kepa, D. Ross, and M.E. Long. 2003. Kinetics of NAD(P)H:Quinone Oxidoreductase I (NQO1) Inhibition by Mitomycin C in Vitro and in Vivo. J. Pharmacol. & Exp. Therapeutics. 305:1079-1086.  
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