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Клетки эндотелия аорты быка: BAOEC. Первичные клеточные линии Cell Applications.

Bovine Aortic Endothelial Cells: BAOEC

Клетки Эндотелия Аорты Быка (BAOEC) предоставляют прекрасную модельную систему для изучения всех аспектов сердечно-сосудистых функций и заболеваний, таких как важнейшие сигнальные пути и механизмы, связанные с правильным функционированием эндотелия, включая ангиогенез, проницаемость, адаптацию к потоку,  продукцию оксида азота и связанные с диабетом осложнения. BAOEC могут также использоваться для поиска полезных модуляторов и систем доставки для терапевтического использования, и для разработки каркасов, поверхностей и материалов для инженерии и трехмерного моделирования тканей.

BAOEC от Cell Applications, Inc. были использованы в десятках исследовательских публикаций, например:

(Текст на языке оригинала)
  • Determine that simvastatin modulates beta-adrenergic signaling in vascular wall by inhibiting cAMP accumulation in response to epinephrine in a mechanism involving downregulation of Galpha(s) translation via Akt/mTOR/eIF4/4EBP pathway
  • Elucidate the PKA-a signaling in endothelial cells by showing that it directly phosphorylates FoxO1 to regulate expression of VCAM-1
  • Identify CaMKKβ and LKB1 as critical determinants of simvastatin-dependent activation of AMPK- and Rac1-modulated signaling and reveal that Rac1 in turn regulates LKB1 phosphorylation
  • Demonstrate that Chondromodulin-I (ChM-I), a cartilage-derived angiogenesis inhibitor, impairs the VEGF-A-induced Rac1/Cdc42 activity leading to destabilized lamellipodial extensions and decreased motility of endothelial cells
  • Demonstrate that cofilin-mediated actin alignment in the direction of shear stress is required for endothelial barrier integrity and that p190RhoGAP links integrins and caveolin-1/caveolae to RhoA in a mechanotransduction cascade that participates in endothelial adaptation to flow
  • Show that activation of RhoA/ROCK/p38 MAPK pathway causes increased endothelial arginase activity/expression and is the key mediator of endothelial dysfunction and decreased NO production precipitated by either oxidative stress-activated PKC, or by angiotensin II-activated Gα12/13 G proteins coupled to AT1 receptors
  • Demonstrate that activation of mTOR/p70S6K by angiotensin II may contribute to impairment of insulin-stimulated vasodilation through phosphorylation of IRS-1 at Ser636/639
  • Discover that testosterone induces a non-genomic membrane-initiated Ca2+ dependent signaling pathway that leads to activation of NF-kB, providing an explanation for why men are predisposed to earlier onset of atherosclerosis
  • Demonstrate that increase in salt concentration, observed in hypertension patients or in individuals with high salt intake, suppresses NO synthase activity, contributing to the development of hypertension
  • Show that valsartan, a selective angiotensin II type 1 receptor (AT1R) blocker, increases NO production via Src/PI3K/Akt signaling that leads to phosphorylation of NO synthase
  • Determine that long-chain polyunsaturated fatty acids exert their beneficial effects on cardiovascular health via activation of B2 receptor leading to elevated expression of NO synthase
  • Show that transient receptor potential vanilloid type 1 (TRPV1) activation by evodiamine or capsaicin initiates two Ca2+-dependent signaling pathways, both resulting in activation of NO synthase: one is PI3K/Akt/CaMKII activation, which leads to NO synthase phosphorylation at Ser1179 and Ser635, and the other involves PP2B-dependent dephosphorylation of PKC leading to decreased phosphorylation of NO synthase at Thr497
  • Discover that LDL-induced endothelial disfunction is mediated by epigenetic upregulation of p66shc promoter increasing expression of p66shc which then stimulates expression of ICAM-1 and inhibits expression of thrombomodulin, leading to stimulated adhesion of monocytes and to plasma coagulation on the surface of endothelial cells
  • Elucidate the involvement of AMPK cascade and autophagy in mediating beneficial cardiovascular effects of green tea;
  • Show, along with Bovine Brain Microvascular Endothelial Cells, also от Cell Applications, Inc., that brain microvasculature is more sensitive to pathogenesis, compared to large vessel endothelia, by demonstrating that C-reactive protein (CRP), a cardiovascular risk factor, induces higher oxidative stress in the brain microvasculature due to higher local expression of the CRP-receptors CD16, CD32 and of the NAD(P)H-oxidase subunit p22phox, and that brain microvascular endothelial cells show higher sensitivity to oxidative stress generated by advanced glycation end products due to stronger VEGF expression leading to increased permeability
  • Improve the efficiency of small molecule cancer therapeutics by prolonging their cytoplasm stay
  • Construct an expression cassette to maximize targeted transgene expression in large vessel endothelia, develop new viral-based vectors an evaluate apoA-I, IL-10 and NO synthase potential for for atheroprotective human gene therapy, and design scaffolds, surfaces and materials for tissue engineering and 3D modeling, as well as for therapies aimed to prevent stent thrombosis
  • Show that erythropoietin (EPO)-mediated activation of NO synthase involves AMPK-dependent signaling, which leads to enhanced phosphorylation of βCR and NO synthase


Normal aorta of USDA-inspected cattle. Each lot is tested negative for mycoplasma, bacteria, and fungi.
Cryopreserved ampoule:
2nd passage, >500,000 cells in Bovine Endothelial Cell Growth Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved BAOEC(B304-05), 500 ml Bovine Endothelial Cell Growth Medium (B211-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
Shipped in Bovine Endothelial Cell Medium at 3rd passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 16 doublings



Pugh, R., J. Slee, S. Farwell, Y. Li, T. Barthol, W. Patton and L. Lowe-Krentz. 2016. Transmembrane protein 184A is a receptor required for vascular smooth muscle cell responses to heparin. JBC, doi: 10.1074/jbc.M115.681122.
Crowe, M., C. Lieven, A. Thompson, N. Sheibani, and L. Levin. 2015. Borane-protected Phosphines are redox-active radioprotective Agents for endothelial Cells. Redox Biology, doi:10.1016/j.redox.2015.06.015.
Bloom, A., and N. Winograd. 2014. Dyeenhanced imaging of mammalian cells with SIMS. Surface and Interface Analysis. 46:177-180.
Browning, M., V. Guiza, B. Russel, J. Rivera, S. Cereceres, M. Höök, M. Hahn, and E. Cosgriff-Hernandez. 2014. Endothelial cell response to chemical, biological, and physical cues in bioactive hydrogels. Tissue Engineering Part A, 20:3130-3141.
Miyashita, S., K. Niwa, T. Watanabe, and Y. Sagane. 2014. Host-cell specificity and transcytosis of nontoxic nonhemagglutinin protein of botulinum neurotoxin serotype D. FEMS Microbiology Letters, Online: 1 August.
Pun, P.B., A. Logan, V. Darley-Usmar, B. Chacko, M.S. Johnson, G.W. Huang, S. Rogatti, T.A. Prime, C. Methner, T. Krieg, I.M. Fearnley, L. Larsen, D. Larsen, K.E. Menger, Y. Collins, A.M. James, G.D. Kishore Kumar, R.C. Hartley, R.A.J. Smith, and M.P. Murphy. 2014. A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes. Free Radical Biology and Medicine. 67:437-50
Rahman, W., S. Corde, N. Yagi, S. Aziz, N. Annabell, and M. Geso. 2014. Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photon beams. International Journal of Nanomedicine, 9:2459–2467.
Candelario, J., and M. Chachisvilis. 2013. Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids. PloS one. 8:e68151.
Ching, L.C., J.F. Zhao, K.H. Su, S.K. Shyue, C.P. Hsu, T.M. Lu, S.J. Lin, and T.S. Lee. 2013. Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C. Acta Physiologica. 209:124-135.
Huang, J.-H., J. Kim, Y. Ding, A. Jayaraman, and V.M. Ugaz. 2013. Embedding Synthetic Microvascular Networks in Poly(Lactic Acid) Substrates with Rounded Cross-Sections for Cell Culture Applications. PloS one. 8:e73188.
Kim, H.-S., V. Montana, H.-J. Jang, V. Parpura, and J.-a. Kim. 2013. Epigallocatechin-gallate (EGCG) stimulates autophagy in vascular endothelial cells: A potential role for reducing lipid accumulation. Journal of Biological Chemistry. 288:22706. doi:22710.21074/jbc.P22113.477505
Slee, J.B., and L.J. Lowe-Krentz. 2013. Actin realignment and cofilin regulation are essential for barrier integrity during shear stress. Journal of cellular biochemistry. 114:782-795.
Chandra, S., M.J. Romero, A. Shatanawi, A.M. Alkilany, R.B. Caldwell, and R.W. Caldwell. 2012. Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway. British journal of pharmacology. 165:506-519.
Hou, H.-H., B.D. Hammock, K.-H. Su, C. Morisseau, Y.R. Kou, S. Imaoka, A. Oguro, S.-K. Shyue, J.-F. Zhao, and T.-S. Lee. 2012. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovascular Research. 93:120-129.
Jiang, B., L. Du, R. Flynn, N. Dronadula, J. Zhang, F. Kim, and D. Dichek. 2012. Overexpression of Endothelial Nitric Oxide Synthase Improves Endothelium-Dependent Vasodilation in Arteries Infused with Helper-Dependent Adenovirus. Human Gene Therapy. 23:1166-1175.
Kim, J.-a., H.-J. Jang, L.A. Martinez-Lemus, and J.R. Sowers. 2012. Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. American Journal of Physiology - Endocrinology and Metabolism. 302:E201-E208.
Kim, Y.-R., C.-S. Kim, A. Naqvi, A. Kumar, S. Kumar, T.A. Hoffman, and K. Irani. 2012. Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction. American Journal of Physiology - Heart and Circulatory Physiology. 303:H189-H196.
Kitagawa, T., H. Kosuge, M. Uchida, M. Dua, Y. Iida, R. Dalman, T. Douglas, and M. McConnell. 2012. RGD-Conjugated Human Ferritin Nanoparticles for Imaging Vascular Inflammation and Angiogenesis in Experimental Carotid and Aortic Disease. Mol Imaging Biol. 14:315-324.
Kou, R., T. Shiroto, J.L. Sartoretto, and T. Michel. 2012. Suppression of Gαs synthesis by simvastatin treatment of vascular endothelial cells. The Journal of biological chemistry. 287:2643-2651.
McGrath, K., X. Li, K. Gaus, P. Williams, D. Celermajer, D. Handelsman, and A. Heather. 2012. Androgens Rapidly Activate Nuclear Factor-Kappa B via Intracellular Ca 2+ Signalling in Human Vascular Endothelial Cells. Journal of Steroids & Hormonal Science:S2:005. doi:010.4172/2157-7536.S4172-4005.
Niiya, Y., T. Abumiya, S.-i. Yamagishi, J.-i. Takino, and M. Takeuchi. 2012. Advanced Glycation End Products Increase Permeability of Brain Microvascular Endothelial Cells through Reactive Oxygen Species–Induced Vascular Endothelial Growth Factor Expression. Journal of Stroke and Cerebrovascular Diseases. 21:293-298.
Santiago, F.S. 2012. Regulatory Mechanisms in Vascular Injury and Repair. In Faculty of Medicine
Su, K.-H., Y.-B. Yu, H.-H. Hou, J.-F. Zhao, Y.R. Kou, L.-C. Cheng, S.-K. Shyue, and T.-S. Lee. 2012. AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase. Journal of cellular physiology. 227:3053-3062.
Baek, J.H., C.E.N. Reiter, D.J. Manalo, P.W. Buehler, R.C. Hider, and A.I. Alayash. 2011. Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1809:262-268.
Ching, L.-C., Y.R. Kou, S.-K. Shyue, K.-H. Su, J. Wei, L.-C. Cheng, Y.-B. Yu, C.-C. Pan, and T.-S. Lee. 2011. Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1. Cardiovascular Research. 91:492-501.
Dronadula, N., L. Du, R. Flynn, J. Buckler, J. Kho, Z. Jiang, S. Tanaka, and D. Dichek. 2011. Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels. Gene Therapy, 18:501-508.
Du, L., N. Dronadula, S. Tanaka, and D.A. Dichek. 2011. Helper-dependent adenoviral vector achieves prolonged, stable expression of interleukin-10 in rabbit carotid arteries but does not limit early atherogenesis. Hum Gene Ther. 22:959-968.
Fatisson, J., F. Azari, and N. Tufenkji. 2011. Real-time QCM-D monitoring of cellular responses to different cytomorphic agents. Biosensors and Bioelectronics. 26:3207-3212.
Flynn, R., K. Qian, C. Tang, N. Dronadula, J.M. Buckler, B. Jiang, S. Wen, H.L. Dichek, and D.A. Dichek. 2011. Expression of Apolipoprotein A-I in Rabbit Carotid Endothelium Protects Against Atherosclerosis. Molecular therapy : the journal of the American Society of Gene Therapy. 19:1833-1841.
Fossey, S., M. Bear, W. Kisseberth, M. Pennell, and C. London. 2011. Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. BMC cancer. 11:125.
Junkin, M. 2011. Microenvironments for study of myogenesis spatial organization and endothelial cell small messenger signaling. The University of Arizona, PhD dissertation.
Lee, J.-W., H. Chen, P. Pullikotil, and M.J. Quon. 2011. Protein Kinase A-α Directly Phosphorylates FoxO1 in Vascular Endothelial Cells to Regulate Expression of Vascular Cellular Adhesion Molecule-1 mRNA. Journal of Biological Chemistry. 286:6423-6432.
Shatanawi, A., M.J. Romero, J.A. Iddings, S. Chandra, N.S. Umapathy, A.D. Verin, R.B. Caldwell, and R.W. Caldwell. 2011. Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway. American Journal of Physiology - Cell Physiology. 300:C1181-C1192.
Slyvka, Y., Z. Wang, J. Yee, S.R. Inman, and F.V. Nowak. 2011. Antioxidant diet, gender and age affect renal expression of nitric oxide synthases in obese diabetic rats. Nitric Oxide. 24:50-60.
Su, K.-H., S.-K. Shyue, Y.R. Kou, L.-C. Ching, A.-N. Chiang, Y.-B. Yu, C.-Y. Chen, C.-C. Pan, and T.-S. Lee. 2011. β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. Journal of cellular physiology. 226:3330-3339.
Yang, B., C. Radel, D. Hughes, S. Kelemen, and V. Rizzo. 2011. p190 RhoGTPase-Activating Protein Links the β1 Integrin/Caveolin-1 Mechanosignaling Complex to RhoA and Actin Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 31:376-383.
Closhen, D., B. Bender, H.J. Luhmann, and C.R.W. Kuhlmann. 2010. CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells. Cytokine. 50:117-120.
Loya, M.C., K.S. Brammer, C. Choi, L.-H. Chen, and S. Jin. 2010. Plasma-induced nanopillars on bare metal coronary stent surface for enhanced endothelialization. Acta Biomaterialia. 6:4589-4595.
Miura, S., K. Mitsui, T. Heishi, C. Shukunami, K. Sekiguchi, J. Kondo, Y. Sato, and Y. Hiraki. 2010. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor. Experimental cell research. 316:775-788.
Reiter, C.E.N., J.-a. Kim, and M.J. Quon. 2010. Green Tea Polyphenol Epigallocatechin Gallate Reduces Endothelin-1 Expression and Secretion in Vascular Endothelial Cells: Roles for AMP-Activated Protein Kinase, Akt, and FOXO1. Endocrinology. 151:103-114.
Thebaud, N. 2010. Cellules endothéliales issues de progéniteurs humains : des acteurs pertinents en ingénierie vasculaire? PhD Dissertation, L’UNIVERSITÉ BORDEAUX 2.
Dilda, P.J., S.p. Decollogne, L. Weerakoon, M.D. Norris, M. Haber, J.D. Allen, and P.J. Hogg. 2009. Optimization of the Antitumor Efficacy of a Synthetic Mitochondrial Toxin by Increasing the Residence Time in the Cytosol. Journal of Medicinal Chemistry. 52:6209-6216.
Kou, R., J. Sartoretto, and T. Michel. 2009. Regulation of Rac1 by Simvastatin in Endothelial Cells: DIFFERENTIAL ROLES OF AMP-ACTIVATED PROTEIN KINASE AND CALMODULIN-DEPENDENT KINASE KINASE-β. Journal of Biological Chemistry. 284:14734-14743.
Li, J., J. White, L. Guo, X. Zhao, J. Wang, E.J. Smart, and X.A. Li. 2009. Salt inactivates endothelial nitric oxide synthase in endothelial cells. The Journal of nutrition. 139:447-451.
Meijering, B.D.M., L.J.M. Juffermans, A. van Wamel, R.H. Henning, I.S. Zuhorn, M. Emmer, A.M.G. Versteilen, W.J. Paulus, W.H. van Gilst, K. Kooiman, N. de Jong, R.J.P. Musters, L.E. Deelman, and O. Kamp. 2009. Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation. Circulation research. 104:679-687.
Su, K.-H., J.-Y. Tsai, Y.R. Kou, A.-N. Chiang, S.-H. Hsiao, Y.-L. Wu, H.-H. Hou, C.-C. Pan, S.-K. Shyue, and T.-S. Lee. 2009. Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovascular Research. 82:468-475.
Chen, H., A.S. Lin, Y. Li, C.E.N. Reiter, M.R. Ver, and M.J. Quon. 2008. Dehydroepiandrosterone Stimulates Phosphorylation of FoxO1 in Vascular Endothelial Cells via Phosphatidylinositol 3-Kinase- and Protein Kinase A-dependent Signaling Pathways to Regulate ET-1 Synthesis and Secretion. Journal of Biological Chemistry. 283:29228-29238.
Chen, H., Y.C. Levine, D.E. Golan, T. Michel, and A.J. Lin. 2008. Atrial Natriuretic Peptide-initiated cGMP Pathways Regulate Vasodilator-stimulated Phosphoprotein Phosphorylation and Angiogenesis in Vascular Endothelium. Journal of Biological Chemistry. 283:4439-4447.
Fan, L.J., and T. Karino. 2008. Effect of serum concentration on adhesion of monocytic THP-1 cells onto cultured EC monolayer and EC-SMC co-culture. Journal of Zhejiang University. Science. B. 9:623-629.
Hamilton, R.T., L. Asatryan, J.T. Nilsen, J.M. Isas, T.K. Gallaher, T. Sawamura, and T.K. Hsiai. 2008. LDL protein nitration: Implication for LDL protein unfolding. Archives of biochemistry and biophysics. 479:1-14.
Hamilton, R.T.L. 2008. LDL protein nitration: Implication for protein unfolding and mitochondrial function by p-JNK-2. PhD thesis, UNIVERSITY OF SOUTHERN CALIFORNIA.
Igarashi, K., and M. Miura. 2008. Inhibition of a Radiation-Induced Senescence-Like Phenotype: A Possible Mechanism for Potentially Lethal Damage Repair in Vascular Endothelial Cells. Radiation Research. 170:534-539.
Mathews, D.T., Y.A. Birney, P.A. Cahill, and G.B. McGuinness. 2008. Vascular cell viability on polyvinyl alcohol hydrogels modified with water-soluble and -insoluble chitosan. Journal of biomedical materials research. Part B, Applied biomaterials. 84:531-540.
Mowbray, A.L. 2008. The role of peroxiredoxins as mechanosensitive antioxidants in endothelial cells. Georgia Institute of Technology, PhD dissertation.
Mowbray, A.L., D.-H. Kang, S.G. Rhee, S.W. Kang, and H. Jo. 2008. Laminar Shear Stress Up-regulates Peroxiredoxins (PRX) in Endothelial Cells: PRX 1 AS A MECHANOSENSITIVE ANTIOXIDANT. Journal of Biological Chemistry. 283:1622-1627.
Song, H. 2008. Endothelial bone morphogenic protein 4 and bone morphogenic protein receptor II expression in inflammation and atherosclerosis. Ph.D. thesis, GEORGIA INSTITUTE OF TECHNOLOGY.
Stoffels, E., A.J.M. Roks, and L.E. Deelman. 2008. Delayed Effects of Cold Atmospheric Plasma on Vascular Cells. Plasma Processes and Polymers. 5:599-605.
Wang, Y., and S. Lu. 2008. The application of FRET biosensors to visualize Src activation. In Proc. SPIE Vol. 6868. 68680A-68680A-68689.
He, X., and T. Karino. 2007. Effects of a shear flow and water filtration on the cell layer of a hybrid vascular graft. Biomechanics at Micro-and Nanoscale Levels. 4:96-106.
Iantorno, M., H. Chen, J.-a. Kim, M. Tesauro, D. Lauro, C. Cardillo, and M.J. Quon. 2007. Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells. American Journal of Physiology - Endocrinology and Metabolism. 292:E756-E764.
Kim, J.-a., G. Formoso, Y. Li, M.A. Potenza, F.L. Marasciulo, M. Montagnani, and M.J. Quon. 2007. Epigallocatechin Gallate, a Green Tea Polyphenol, Mediates NO-dependent Vasodilation Using Signaling Pathways in Vascular Endothelium Requiring Reactive Oxygen Species and Fyn. Journal of Biological Chemistry. 282:13736-13745.
Kishi, A., K. Yuasa, T. Matsukawa, T. Matsui, Y. Yamada, and I. Yamada. 2007. Agent for preventing arteriosclerosis. Patent Application US 20110009616 A1.
Kou, R., and T. Michel. 2007. Epinephrine Regulation of the Endothelial Nitric-oxide Synthase: ROLES OF RAC1 AND β3-ADRENERGIC RECEPTORS IN ENDOTHELIAL NO SIGNALING. Journal of Biological Chemistry. 282:32719-32729.
Ohashi, T., Y. Sugaya, N. Sakamoto, and M. Sato. 2007. Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells. Journal of Biomechanics. 40:2399-2405.
Radel, C., M. Carlile-Klusacek, and V. Rizzo. 2007. Participation of caveolae in β1 integrin-mediated mechanotransduction. Biochemical and biophysical research communications. 358:626-631.
Sakai, T., K. Balasubramanian, S. Maiti, J.B. Halder, and A.J. Schroit. 2007. Plasmin-Cleaved β-2-Glycoprotein 1 Is an Inhibitor of Angiogenesis. The American journal of pathology. 171:1659-1669.
Yang, B., and V. Rizzo. 2007. TNF-α potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells. American Journal of Physiology-Heart and Circulatory Physiology. 292:H954-H962.
DeMaio, L., M. Rouhanizadeh, S. Reddy, A. Sevanian, J. Hwang, and T.K. Hsiai. 2006. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. American Journal of Physiology - Heart and Circulatory Physiology. 290:H674-H683.
Formoso, G., H. Chen, J.-a. Kim, M. Montagnani, A. Consoli, and M.J. Quon. 2006. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase-and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Molecular endocrinology. 20:1153-1163.
Liu, M.Y., M. Eyries, C. Zhang, F.S. Santiago, and L.M. Khachigian. 2006. Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. Blood. 107:2322-2329.
Mathews, D.T. 2006. Characterisation of polyvinyl alcohol hydrogels modified with chitosan for cardiovascular applications. Dublin City University, PhD dissertation.
Mohri, S., J. Shimizu, N. Goda, T. Miyasaka, A. Fujita, M. Nakamura, and F. Kajiya. 2006. Measurements of CO2, lactic acid and sodium bicarbonate secreted by cultured cells using a flow-through type pH/CO2 sensor system based on ISFET. Sensors and Actuators B: Chemical. 115:519-525.
Niiya, Y., T. Abumiya, H. Shichinohe, S. Kuroda, S. Kikuchi, M. Ieko, S.-i. Yamagishi, M. Takeuchi, T. Sato, and Y. Iwasaki. 2006. Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species. Brain research. 1108:179-187.
Ouedraogo, R., X. Wu, S.-Q. Xu, L. Fuchsel, H. Motoshima, K. Mahadev, K. Hough, R. Scalia, and B.J. Goldstein. 2006. Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells: Evidence for Involvement of a cAMP Signaling Pathway. Diabetes. 55:1840-1846.
Yang, B., T.N. Oo, and V. Rizzo. 2006. Lipid rafts mediate H2O2 prosurvival effects in cultured endothelial cells. The FASEB Journal. 20:1501-1503.
Bonello, M., Y. Bobryshev, and L. Khachigian. 2005. Peroxide-Inducible Ets-1 Mediates Platelet-Derived Growth Factor Receptor-α Gene Transcription in Vascular Smooth Muscle Cells. Am J Pathol, 167:1149-1159.
Dilda, P.J., A.S. Don, K.M. Tanabe, V.J. Higgins, J.D. Allen, I.W. Dawes, and P.J. Hogg. 2005. Mechanism of Selectivity of an Angiogenesis Inhibitor From Screening a Genome-Wide Set of Saccharomyces cerevisiae Deletion Strains. Journal of the National Cancer Institute. 97:1539-1547.
Kieft, I., D. Darios, A. Roks and E. Stoffels. 2015. Plasma treatment of mammalian vascular cells: a quantitative description. Plasma Science, IEEE Transactions, 33:771-775.
Kou, R., S. SenBanerjee, M.K. Jain, and T. Michel. 2005. Differential Regulation of Vascular Endothelial Growth Factor Receptors (VEGFR) Revealed by RNA Interference:  Interactions of VEGFR-1 and VEGFR-2 in Endothelial Cell Signaling†. Biochemistry. 44:15064-15073.
Potenza, M.A., F.L. Marasciulo, D.M. Chieppa, G.S. Brigiani, G. Formoso, M.J. Quon, and M. Montagnani. 2005. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. American Journal of Physiology - Heart and Circulatory Physiology. 289:H813-H822.
Death, A.K., K.C. McGrath, M.A. Sader, S. Nakhla, W. Jessup, D.J. Handelsman, and D.S. Celermajer. 2004. Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-κB-dependent pathway. Endocrinology. 145:1889-1897.
Motoshima, H., X. Wu, K. Mahadev, and B.J. Goldstein. 2004. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochemical and biophysical research communications. 315:264-271.
Niwa, K., T. Kado, J. Sakai, and T. Karino. 2004. The effects of a shear flow on the uptake of LDL and acetylated LDL by an EC monoculture and an EC–SMC coculture. Ann Biomed Eng. 32:537-543.
Chen, H., M. Montagnani, T. Funahashi, I. Shimomura, and M.J. Quon. 2003. Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells. Journal of Biological Chemistry. 278:45021-45026.
Khachigian, L. 2002. Treatment of cancer. Patent Application US 20030203864 A1.
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Basal medium (contains no growth supplement).В  Add GS before use. B210-500 6602.41 руб.

Basal medium & growth supplement sold together packaged separately B211K-500 13080.49 руб.

Added to Basal Medium to create Growth Medium B211-GS 5855.07 руб.

For general cryopreservation of most primary cells. Contains FBS & DMSO. 040-50 6228.74 руб.

Cryopreserved BAOEC B304-05 67893.8 руб.

BAOEC Total Kit: Media, Subculture Reagents & CellsВ B304K-05 85209.67 руб.

25 x 24-Well Rxns TF101KS 6222.62 руб.
250 x 24-Well Rxns TF101K 49829.91 руб.

Proliferating BAOEC B305-6w 85334 руб.
Proliferating BAOEC B305-25 67893.8 руб.
Proliferating BAOEC B305-75 91562.74 руб.
Proliferating BAOEC B305-96w 100283.52 руб.

100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution 090K 6353.07 руб.

Extended Family Products

Total RNA prepared from Bovine Aortic Endothelial Cells B304-R10 40486.8 руб.
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500 tests 028-01 16070.53 руб.

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