BACKGROUND Echinoderm microtubule-associated proteinlike 4 (EML4) is a 120 kDa microtubule-associated WD repeat protein of the echinoderm microtubule-associated protein family (1). The expression of EML4 is necessary for correct intracellular microtubule network formation (2). EML4 protein expression is upregulated during mitosis and downregulated during the remaining cell cycle (1). During mitosis, EML4 is heavily phosphorylated and is associated with the mitotic spindle (2). The amino-terminal segment of EML4 is essential for microtubule association and function.
1. Heidebrecht, H.J. et al. (2000) Genomics68, 348-350.
2. Pollmann, M. et al. (2006) Exp. Cell Res.312, 3241-3251.
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