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Anti-Ezh2: Mouse Ezh2 Antibody

BACKGROUND The polycomb group (PcG) proteins are involved in maintaining the silenced state of several developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis (1,2). Enhancer of zeste homolog 2 (Ezh2), a member of this large protein family, contains four conserved regions including domain I, domain II, and a cysteine-rich amino acid stretch that precedes the carboxyl terminal SET domain (3). The SET domain has been linked with histone methyltransferase (HMTase) activity. Moreover, mammalian Ezh2 is a member of a histone deacetylase complex that functions in gene silencing, acting at the level of chromatin structure (4). Ezh2 complexes methylate histone H3 at Lys9 and 27 in vitro, which is thought to be involved in targeting transcriptional regulators to specific loci (5). Ezh2 is deregulated in various tumor types, and its role, both as a primary effector and as a mediator of tumorigenesis, has become a subject of increased interest (6).


1. Seller, W.B. and Loda, M. (2002) Cancer Cell 2, 349-350.
2. Visser, H.P. et al. (2001) Br. J. Haematol.  112, 950-958.
3. Chen, H. et al. (1996) Genomics 38, 30-37.
4. Tonini, T. et al. (2004) Oncogene 23, 4930-4937.
5. Muller, J. et al. (2002) Cell 111, 197-208.
6. Kleer, C.G. et al. (2003) Proc Natl. Acad. Sci. USA 100, 11606-11611.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


Antigen:Recombinant human Ezh2 expressed in E. Coli
Isotype:Mouse IgG
Species & predicted
species cross-
reactivity ( ):
Human, Mouse
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC                  1:400
ICC                  n/d
FACS                n/d
Predicted Molecular
Weight of protein:
98 kDa
Specificity/Sensitivity:Detects endogenous Ezh2 proteins without cross-reactivity with family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.

Mouse Ezh2 Antibody CC10045 по запросу

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