BACKGROUND The GA-binding protein transcription factor, also called nuclear respiratory factor-2 (NRF2), was originally identified by its role in the expression of the adenovirus E4 gene. GA-binding protein alpha chain (GABPA) is one of three GA-binding protein transcription factor subunits, which functions as a DNA-binding subunit.1 The GABP complex contributes to the transcriptional regulation of a number of subunits of mitochondrial enzymes, including cytochrome c oxidase and mitochondrial transcription factor A.2 Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.3
1. Watanabe H et al.: Mol. Cell. Biol. 13: 1385-1391, 1993.
2. Guo A et al.: J. Comp. Neurol. 417: 221-232, 2000.
3. Chrast R et al.: Genomics 28:119-122, 1995.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
An E. coli-expressed recombinant protein containing human GABPA (aa120-190) sequence.
Mouse Monoclonal IgG1
Species & predicted
reactivity ( ):
ICC 1:200 - 1:1000
Weight of protein:
This monoclonal antibody detects endogenous levels of GABPA proteins in various cell lysates.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
*Optimal working dilutions must be determined by end user.