BACKGROUND The GA-binding protein transcription factor, also called nuclear respiratory factor-2 (NRF2), was originally identified by its role in the expression of the adenovirus E4 gene. GA-binding protein alpha chain (GABPA) is one of three GA-binding protein transcription factor subunits, which functions as a DNA-binding subunit.1 The GABP complex contributes to the transcriptional regulation of a number of subunits of mitochondrial enzymes, including cytochrome c oxidase and mitochondrial transcription factor A.2 Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.3
1. Watanabe H et al.: Mol. Cell. Biol. 13: 1385-1391, 1993.
2. Guo A et al.: J. Comp. Neurol. 417: 221-232, 2000.
3. Chrast R et al.: Genomics 28:119-122, 1995.
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