BACKGROUND ALCAM (activated leucocyte cell adhesion molecule, synonym CD166) is a cell adhesion molecule, which belongs to the Ig superfamily. It binds to CD6. Its function is involved in neurite extension by neurons via heterophilic and homophilic interactions. ALCAM may play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.1 For clinical studies, ALCAM is a valuable prognostic and predictive marker in several types of epithelial tumors. Disruption of the ALCAM-mediated adhesiveness by proteolytic sheddases such as ADAM17 has been suggested to have a relevant impact on tumor invasion.2
1. Bowen, M.A. et al: J. Biol. Chem. 271:17390-6, 1996
2. Weichert, W. et al: J. Clin. Pathol. 57:1160-64, 2004
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Immunogen Sequence: EK PDGSPVFIAF RSSTKKSVQY DDVPEYK
Species & predicted
reactivity ( ):
Weight of protein:
|Detects endogenous ALCAM proteins without cross-reactivity with other family members.|
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
*Optimal working dilutions must be determined by end user.