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Anti-AMACR: Mouse alpha-Methylacyl-CoA Racemase Antibody


BACKGROUND AMACR, also known as P504S, is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl, branched carboxylic coenzyme A thioesters and is Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Thus, it plays a crucial role in the beta-oxidation of bile acid intermediates, dietary branched-chain fatty acids, and fatty acid derivatives.1 Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis.2 Alternatively spliced transcript variants have been described. Recent studies showed that AMACR is overexpressed in a variety of neoplasms, such as prostate and colon cancer. AMACR overexpression in human solid tumors is a potential target for cancer treatment.3
 
REFERENCES  
1. Evans, A.J.: J. Clin. Pathol. 56:892-897, 2003
2. Ferdinandusse, S. et al: Nature Genet. 24:188-191, 2000
3. Truong, C.D. et al: Int. J. Clin. Exp. Pathol. 1:518-523, 2008
  
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CP10009
Antigen:
Recombinant human AMACR protein fragment expressed in E. coli.
Isotype:
Mouse IgG2b
Species & predicted
species cross-
reactivity ( ):
Human, Mouse
Applications &
Suggested starting
dilutions:*
WB                  1:500 - 1:2000
IP                    1:50 - 1:100
IHC                  1:200 - 1:1000
ICC                  1:200 - 1:1000
FACS               n/d
Predicted Molecular
Weight of protein:
43 kDa
Specificity/Sensitivity:
Detects endogenous levels of AMACR proteins in normal cell lysates without cross-reactivity with other related proteins.
Storage:
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Mouse alpha-Methylacyl-CoA Racemase Antibody CP10009 34999.97 руб.




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