BACKGROUND CD31, a member of the immunoglobulin superfamily, is a 130 kDa transmembrane glycoprotein also designated as PECAM-1 (platelet endothelial cell adhesion molecule1). CD-31 is normally found on endothelial cells (EC), platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils.1 It plays a major role in the adhesion cascade between EC and the inflammatory cells during inflammation in facilitating leucocyte migration and between EC during angiogenesis.2,3 It has recently been recognized for its angiogenic role. It is one of the best markers for benign and malignant vascular tumors, but also stains plasma cells, monocytes, and megakaryocytes.4
REFERENCES 1. Newman, P. J.. et al: Science 247: 1219, 1990. 2. Kalinowska, A. & Losy, J. : Eur. J. Neurol. 13:1284, 2007. 3. Stockinger, H. et al. (1991). J. Immunol. 145:3889, 1991. 4. Tang, D. G. et al: J. Biol. Chem. 268:22883, 1993.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
E. coli-expressed recombinant human CD31 cytoplasmic protein fragments.
Mouse Monoclonal IgG1
Species & predicted
reactivity ( ):
Detects endogenous levels of human CD31/PECAM-1 proteins.
IHC (Paraffin) n/d
Weight of protein:
Does not cross-react with other endothelial cell proteins
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
*Optimal working dilutions must be determined by end user.