Anti-PER1: Mouse PER1 Antibody |
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BACKGROUND PER1 (Period circadian protein 1; also known as RIGUI) is a master regulator of circadian rhythm and functions in the nucleus to repress expression of the central circadian clock genes. The periodicity of PER1 abundance, nuclear translocation, and transcriptional repression is regulated by PER1 phosphorylation, ubiquitination, and proteasomal degradation (1). It is one component of the circadian clock mechanism which is essential for generating circadian rhythms. It can influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus (2, 3).
REFERENCES
1. Chiu J.C. et al. (2011) Cell145, 357-70
2. Sangoram A.M. et al. (1998) Neuron21, 1101-13
3. Lee Y. et al. (2010) J Cell Sci. 123, 3547-57
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
| Cat.No.: | CC10053 |
| Antigen: | Recombinant mouse PER1 expressed in mammalian cells. |
| Isotype: | Mouse IgG |
Species & predicted species cross- reactivity ( ): | Human, Mouse |
Applications & Suggested starting dilutions:* | WB 1:500 IP n/d IHC n/d ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 140 kDa |
| Specificity/Sensitivity: | Detects endogenous PER1 proteins without cross-reactivity with other family members. |
| Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
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