BACKGROUND The Vascular Endothelial Growth Factor Receptor (VEGFR) family has three members: VEGFR-1 (also known as flt-1), VEGFR-2 (KDR/flk-1), and VEGFR-3 (FLT4). In VEGFR-3, the fifth Ig homology domain of the extracellular portion is proteolytically cleaved and the resulting polypeptides remain linked by twodisulfide bonds.1 The ligands binding to VEGFRs belong tothe VEGF family of growth factors, which has five cellular members: VEGF, placenta growth factor (PlGF), VEGF-B, VEGF-C, VEGF-D, and the recently cloned viral VEGF homologue VEGF-E.2 VEGFR-3 is requiredfor cardiovascular development during embryogenesis. In adults,this receptor is expressed in lymphatic endothelial cells. VEGF-C and VEGF-D are VEGFR3 ligands. The binding of VEGF ligands to VEGFRs activates VEGFR3 signaling, which regulates cardiovascular development, angiogenesis, and lymphangiogenesis.3
1. Otrock, Z.K. et al. : Blood Cells Mol Dis. 38:258, 2007.
2. Taipale, J. et al.: Curr Top Microbiol Immunol. 237:85, 1999.
3. Su, J.L. et al.: Br J Cancer. 96:541, 2007.
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E. coli-expressed expressed cytoplasmic domain of human VEGF receptor-3.
Rabbit Polyclonal IgG
Species & predicted
reactivity ( ):
IHC (Paraffin) n/d
Weight of protein:
Anti-VEGFR3 specifically detects endogenously expressed human VEGF receptor-3. This antibody does not cross-react with other VEGFR-family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
*Optimal working dilutions must be determined by end user.