MIP-3 α / CCL20: Human Macrophage Inflammatory Protein-3 alpha

BACKGROUND Macrophage Inflammatory Protein-3 alpha (MIP-3α), also called CCL20, is expressed in the liver, lungs, lymph nodes and peripheral blood lymphocytes. MIP-3α is strongly up regulated by inflammatory signals, and down regulated by the anti-inflammatory cytokine IL-10. MIP3α signals through the G protein-coupled receptor, CCR6, and acts as a chemoattractant to lymphocytes and dendritic cells.

Recombinant human MIP-3α is a non-glycosylated protein, consisting of 70 amino acids and a molecular weight of 8.0 kDa.

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