A hallmark of cancer is uncontrolled cell proliferation caused by deregulation of multiple signaling pathways associated with cell replication, metabolism and programmed cell death
Cytostatic nucleotides are substrate analogs of physiological nucleotides that inhibit cell proliferation by interfering with cellular targets involved in DNA/RNA synthesis and nucleotide metabolism.
In vivo or cell culture experiments
can be performed using the non-phosphorylated nucleoside variant of a cytostatic nucleotide
that is metabolized by multiple cellular kinases to its active phosphorylated forms (NMP → NDP → NTP).
Alternatively, a number of mono-, di- and triphosphorylated analogs
of cytostatic nucleotides are available for functional in vitro experiments
Please refer to the corresponding data sheet for detailed application data.