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Цитостатические нуклеотиды

Nucleotides by Application  /  ... in Drug Discovery - Cytostatic Nucleotides

A hallmark of cancer is uncontrolled cell proliferation caused by deregulation of multiple signaling pathways associated with cell replication, metabolism and programmed cell death[1].

Cytostatic nucleotides are substrate analogs of physiological nucleotides that inhibit cell proliferation by interfering with cellular targets involved in DNA/RNA synthesis and nucleotide metabolism.

In vivo or cell culture experiments can be performed using the non-phosphorylated nucleoside variant of a cytostatic nucleotide that is metabolized by multiple cellular kinases to its active phosphorylated forms (NMP → NDP → NTP).

Alternatively, a number of mono-, di- and triphosphorylated analogs of cytostatic nucleotides are available for functional in vitro experiments (Tab. 1).

Please refer to the corresponding data sheet for detailed application data.
 


Table 1: Available cytostatic nucleosides and corresponding nucleotide variants.

NucleosideNucleotide
Monophosphate (NMP)
Nucleotide
Diphosphate (NDP)
Nucleotide
Triphosphate (NTP)
ara-A
(Vidarabine)
ara-AMP
ara-ATP
Cl-F-ara-A
(Clofarabine)
Cl-F-ara-AMP
Cl-F-ara-ATP
2'Cl-Adenosine

2'Cl-dATP
ara-C
(Cytarabine)
ara-CMPara-CDPara-CTP
dF-dC
(Gemcitabine)
dF-dCMPdF-dCDPdF-dCTP
5F-U
(5-Fluoruracil)
5F-dUMP
5F-dUTP
6-Thio-I
(6-Thio-inosine)
6-Thio-IMP6-Thio-IDP6-Thio-ITP
6-Methylthio-I
(6-Methylthio-inosine)
6-Methylthio-IMP6-Methylthio-IDP6-Methylthio-ITP
 


 
 

(2'Cl-dATP)
НазваниеКодЦена
L pack NU-148L 41643.39 руб. 5 x 50 Units
S pack NU-148S 14216.43 руб. 50 Units



(5F-dUMP)
НазваниеКодЦена
L pack NU-153L 41643.39 руб. 5 x 50 Units
S pack NU-153S 14216.43 руб. 50 Units



(5F-dUTP)
НазваниеКодЦена
L pack NU-154L 45371.09 руб. 5 x 50 Units
S pack NU-154S 14216.43 руб. 50 Units



6-Thio-inosine-5'-diphosphate
НазваниеКодЦена
L pack NU-1210L 41643.39 руб. 5 x 100 Units
S pack NU-1210S 14216.43 руб. 100 Units



6-Thio-Inosine-5'-monophosphate
НазваниеКодЦена
L pack NU-1148L 41643.39 руб. 5 x 100 Units
S pack NU-1148S 14216.43 руб. 100 Units



6-Thio-Inosine-5'-triphosphate
НазваниеКодЦена
L pack NU-1110L 41643.39 руб. 5 x 100 Units
S pack NU-1110S 14216.43 руб. 100 Units



НазваниеКодЦена
L pack NU-1132L 41643.39 руб. 5 x 100 Units
S pack NU-1132S 14216.43 руб. 100 Units



НазваниеКодЦена
L pack NU-1131L 41643.39 руб. 5 x 150 Units
S pack NU-1131S 14216.43 руб. 150 Units



НазваниеКодЦена
L pack NU-1133L 41643.39 руб. 5 x 150 Units
S pack NU-1133S 14216.43 руб. 150 Units



Vidarabine triphosphate, Sodium Salt
НазваниеКодЦена
L pack NU-1111L 41643.39 руб. 5 x 50 Units
S pack NU-1111S 14216.43 руб. 50 Units



Cytarabine diphosphate, Sodium salt
НазваниеКодЦена
L pack NU-1171L 41643.39 руб. 5 x 50 Units
S pack NU-1171S 14216.43 руб. 50 Units



Cytarabine triphosphate, Sodium salt
НазваниеКодЦена
L pack NU-1170L 43726.43 руб. 5 x 100 Units
S pack NU-1170S 14928 руб. 100 Units



Triethylammonium salt
Datasheet
НазваниеКодЦена
Clofarabine-5'-monophosphate NU-873 101123.67 руб. 3 mg



Triethylammonium salt
Datasheet
НазваниеКодЦена
Clofarabine-5'-triphosphate NU-874 101123.67 руб. 5 μmol



Sodium Salt
Datasheet
НазваниеКодЦена
L pack NU-1608L 43726.43 руб. 5 x 20 Units
S pack NU-1608S 14928 руб. 20 Units



Sodium salt
Datasheet
НазваниеКодЦена
Gemcitabine-5'-monophosphate NU-871 101123.67 руб. 2 mg



Sodium Salt
Datasheet
НазваниеКодЦена
L pack NU-1607L 43726.43 руб. 5 x 50 Units
S pack NU-1607S 14928 руб. 50 Units




Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой