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Фибробласты кожи человека: HDF. Первичные клеточные линии Cell Applications.

Human Dermal Fibroblasts: HDF

HDF Фибробласты Кожи Человека (HDF) отвечают за выработку клеточного матрикса, формирующего соединительную ткань кожи, и играют важную роль при заживлении ран. HDF от Cell Applications, Inc. обеспечивают прекрасную модель для изучения многих аспектов клеточной физиологии и использовались в десятках исследовательских публикаций, особенно связанных с биологией кожи и перепрограммированием/индуцированием плюрипотентных стадий.

HDF от Cell Applications have been instrumental to

(Текст на языке оригинала)
  • Create and characterize induced pluripotent stem cells (iPSC)
  • Demonstrate the activation and efficiency of reprogramming, such as the transition of fibroblasts into platelets, or mesenchymal stromal cells into iPSC
  • Identify markers that distinguish chondrocytes and synovial cells
  • Establish protocols for tissue engineering, biomaterials, and synthetic collagens.
  • Examine molecular gene regulation & activation, epigenetic modifications, histone ubiquitination and miRNA expression.
  • Describe cell physiology and behavior, includinig cell adhesion, integrins, cartilage link protein and elastic fiber formation. Others rely on the cells to characterize mitochondrial metabolism, angiogenesis and tissue remodeling.
  • Provide insights into disease and pathology: UVA effects, stress-induced premature senescence, skin aging, elasticity and dermal integrity, as well as tumor cell pluripotency markers.
  • Develop potential clinical treatments and therapeutics: Cell survival factors and natural antioxidants like astaxanthin. Some investigators have observed approaches that promote wound healing, or protect skin from UVA-induced photo-aging.


Normal human neonatal foreskin or adult skin. Each lot is tested negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Cryopreserved ampoule:
Primary culture, >500,000 cells in Fibroblast Basal Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved HDF (106-05), 500 ml Growth Medium (116-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
Shipped in Growth Medium at 1st passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 16 doublings



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Xu, M., T. Okada, H. Sakai, N. Miyamoto, Y. Yanagisawa, A.E. MacKenzie, S. Hadano, and J.-E. Ikeda. 2002. Functional human NAIP promoter transcription regulatory elements for the NAIP and ΨNAIP genes. Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression. 1574:35-50.

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