BACKGROUND CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction.1 The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.2 Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
1. Klaus, G.G.B. et al: Int. Rev. Immunol. 15:5-31,1997
2. Togo, T. et al: Brain Res. 885:117-21, 2000
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Target Protein Species:
No detectable cross-reactivity
with any other cytokine.
Store at 4°C. Use within 6 months.
ELISA Kits are based on standard sandwich enzyme-linked immunosorbent assay technology. Freshly prepared standards, samples, and solutions are recommended for best results.