BACKGROUND The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of nucleic acid binding proteins that are often found in, but not restricted to, the 40S-ribonucleoprotein particle. Subsets of hnRNPs are strictly nuclear while others shuttle between the nucleus and cytoplasm.1 hnRNP complexes are also major constituents of the spliceosome. They are composed of approximately 30 different proteins, which can bind to nascent pre-mRNA. Members of the hnRNP family have been implicated in many aspects of mRNA maturation/turnover, and in telomere and telomerase regulation. Among these, the hnRNP-A/B proteins form a subgroup of highly related proteins consisting of two adjacent RNA binding domains (RBD) within the N-terminal parts, whereas the C-terminal halves contain almost 50% glycine residues.2 hnRNP A2/B1 has been found overexpressed in the early stages of lung and other cancers.3,4 Thus, hnRNP-A2/B1 can be a marker of carcinogenesis.
1. Ford, LP et al., Oncogene 21:580, 2002.
2. Steiner, G et al., Mol Biol Rep 23:167, 1996.
3. Zhou, J. et al., Lung Cancer. 34:341, 2001.
4. Zhou, J. et al., Breast Cancer Res Treat. 66:217, 2001.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
recombinant human hnRNP-A2/B1 protein
Mouse Monoclonal IgG1
Species & predicted
reactivity ( ):
Weight of protein:
34 & 36 kDa
Reacts specifically with human hnRNP-A2/B1 in Western Blot applications.
Store at 4° for frequent use; at -20° for at least one year
*Optimal working dilutions must be determined by end user.