Anti-TNNI2: Mouse TNNI2 Antibody

BACKGROUND Troponin plays a central role in the Ca2+ regulation of contraction in vertebrate skeletal and cardiac muscles. It consists of three subunits with distinct structure and function, troponin T (TnT), troponin I (TnI), and troponin C (TnC), and their accurate and complex intermolecular interaction, along with tropomyosin, in response to the rapid rise and fall of Ca2+ in cardiac and skeletal myocytes plays a key role in maintaining the normal cardiac pump function and body movement. Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Three troponin I genes have been identified in vertebrates that encode the isoforms expressed in adult cardiac muscle (TNNI3), slow skeletal muscle (TNNI1) and fast skeletal muscle (TNNI2), respectively.¹

Mouse studies show that TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. TNNI2 also suppresses tumor growth in human ovarian carcinoma. Mutations in TNNI2 gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.²
 

REFERENCES  

1. Parmacek, M.S. & Solaro, R.J.: Prog Cardiovasc Dis 47:159-76, 2004
2. Mullen, A.J. & Barton, P.J.R.:Gene 242:313-20, 2000