Human Hippocampal Neurons (HHiN) are derived from normal healthy brain tissue. They provide a model in vitro system for studying neurophysiology, neural plasticity and memory storage. Examining hippocampal neurons in normal and disease conditions will allow a better understanding of brain physiology, disease mechanisms, pathology, and foster advancements in drug development and clinical applications. When cultured under the recommended conditions, HHiN arborize and form complex neurite networks in one week.
The hippocampus, a major brain component located under the cerebral cortex, consists of two hippocampi, one in each side of the brain. Belonging to the limbic system, the hippocampus functions in spacial memory and navigation, and the consolidation of information from short- to long-term memory. Damage, disease or oxygen starvation in this region is associated with Alzheimer's disease, encephalitis, epilepsy and amnesia.