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Human Small Airway Epithelial Cells: HSAEpC

Human Small Airway Epithelial Cells: HSAEpC

Human Small Airway Epithelial Cells (HSAEpC) are isolated from the distal portion of lung tissue in the bronchiole area of the respiratory tract. Located in a region critical to gas exchange and immune response, HSAEpC provide an in vitro model to research cell biology, immunology and pharmaceutical drug discovery.  The small (pulmonary) epithelium forms a continuous lining in the airways, offering mechanical and immunological barriers against the external environment, physically protecting the underlying submucosa.
For general cell biology and airway function, the cells provide insights into pulmonary fluid balance, vascular and airway homeostasis and even the lung microbiome. Other work highlights epithelial cell junction integrity, and maintenance of the alveolar barrier integrity that provides first line host defense against inhaled pathogens. HSAEpC help unravel inflammatory signaling pathways, transcription factors and gene expression cascades. Decades of work in lung remodeling, wound healing and repair of surface airway epithelium damage have more recently paved the way to lung organoids and 3D models of small airway epithelium.
Primary HSAEpC offer physiological relevance to the study of respiratory infection, recognition, and immune responses to bacteria, viruses and other foreign invaders like nanoparticles, air pollution and cigarette smoke.  Such insults trigger production of chemokines, cytokines and lipids that mediate inflammation and recruit inflammatory cells. HSAEpC dysregulation has also be studied in terms of apoptosis, superoxide production and the effects of hypoxia or radiation.
HSAEpC are targeted in chronic diseases like bronchiolitis, asthma, COPD, cystic fibrosis, pulmonary hypertension and lung cancer.  Accordingly, the cells find increasing applications for drug discovery assays, in the hope to identify new therapeutic options to treat or prevent airway disorders.  Such tests included compound screening, toxicology, drug uptake and response, in formats ranging from standard 2D assays and microplates to 3D tissue models and airway-on-a-chip technology.


Human Small Airway Epithelial Cells: HSAEpC

TissueNormal healthy human small airway
QCNo bacteria, yeast, fungi, mycoplasma, virus
BioassayAttach, spread, proliferate in Growth Med
Cryovial500,000 HSAEpC (1st passage) frozen in Basal Med w/ 10% FBS, 10% DMSO
KitCryovial frozen HSAEpC (532-05a), Gr Med (512-500), Subculture Rgnt Kit (090K)
ProliferatingShipped in Gr Med, 3rd psg (flasks or plates)
DoublingsAt least 6
ApplicationsLaboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.


Human Small Airway Epithelial Cells: HSAEpC

5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics) 532K-05a по запросу

Frozen HSAEpC (5x10^5) 532-05a по запросу

Actively growing, dividing cells in medium 532-25a по запросу
Actively growing, dividing cells in medium 532-75a по запросу
Actively growing, dividing cells in medium 532-6Wa по запросу
Actively growing, dividing cells in medium 532-96Wa по запросу

Extended Family Products

For general cryopreservation of most primary cells. Contains FBS & DMSO. 040-50 по запросу

100 tests 028-S по запросу
500 tests 028-01 по запросу

124 x 24-Well Rxns TF102K по запросу
25 x 24-Well Rxns TF102KS по запросу

Total RNA prepared from human lung tissue 1H40-50 по запросу
Total RNA prepared from human lung tissue 1H40-250 по запросу

Related Products

Basal medium (contains no growth supplement). Add GS before use. 140-500 по запросу

All-in-one ready-to-use 512-500 по запросу

Basal medium & growth supplement sold together packaged separately 512K-500 по запросу

Added to Basal Medium to create Growth Medium 512-GS по запросу

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