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SW-480, растущая культура

SW-480 growing

Аденокарцинома толстой кишки человека - клеточная линия
2xT25 культуральные колбы
Растущая культура

Технические параметры
ПроизводительCLS Cell Lines Service
Номер в каталоге 330302GR
Ценапо запросу
Фасовка2xT25
 

Product information SW-480 cells


MSDS SW-480 cells


Images of SW-480 cells

Human Colon adenocarcinoma cell line SW-480

Organism: Homo sapiens (human)
Ethnicity: Caucasian
Age: 51 years old
Gender: Male
Tissue: Colon, Grade IV, Dukes' type B
Morphology: Epithelial
Celltype: Adenocarcinoma, colorectal
Growth Properties: Monolayer, adherent
Description: The SW480 cell line originated from a surgical specimen of a primary tumor of a moderately differentiated colon adenocarcinoma. The line is negative for CSAp (CSAp-) and colon antigen 3. The cells are positive for keratin by immunoperoxidase staining. There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. The cells express elevated levels of p53 protein. The line is positive for expression of c-myc, K-ras, H-ras, N-ras, myb, sis and fos oncogenes. N-myc oncogene expression was not detected. Matrilysin, a metalloproteinase associated with tumor invasiveness, is not expressed. The cells have been reported to produce GM-CSF. This line has a mutation in codon 12 of the ras protooncogene, and can be used as a positive control for PCR assays of mutation in this codon.


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